Clomid has been used to induce ovulation for more that thirty years and is often the first fertility drug that couples come in contact with. It is (relatively) inexpensive as fertility drugs go, it is easily taken (orally rather than by injection) and it is the first line drug used for ovulation induction in patients with polycystic ovary syndrome and other ovulatory disorders. Clomiphene Citrate is capable of reacting with all of the tissues in the body that have estrogen receptors. These tissues include hypothalamus, pituitary, ovary, endometrium, vagina and cervix. Clomid influences the way that the four hormones required for ovulation, GnRH, FSH, LH and estradiol, relate and interrelate. In essence it appears that Clomid fools the body into believing that the estrogen level is low. This altered feedback information causes the hypothalamus (an area of the brain) to make and release more gonadotropin releasing hormone (GnRH) which in turn causes the pituitary to make and release more FSH and LH. More follicle stimulating hormone and more luteinizing hormone should result in the release of one or more mature eggs - ovulation. Once ovulating, most pregnancies occur in the first 6 cycles of treatment. Clomid is said to be able to induce ovulation in as much as 85% of the women who use it, though only half of those will actually become pregnant. Most authorities agree that continuing for more than 6 ovulatory cycles in not likely to increase the chances of success. Patients most likely to achieve success with clomiphene therapy include those with: * polycystic ovary syndrome * amenorrhea-galactorrhea syndrome * psychogenicamenorrhea * post-oral-contraceptive amenorrhea * certain cases of secondary amenorrhea of undetermined etiology.